New research reveals that B cells regulate obesity-associated inflammation and type 2 diabetes through two specific mechanisms. The research is from Boston University School of Medicine (BUSM). The study, published in the iProceedings of the National Academies of Sciences/i, indicates the importance of continuing to explore B cells as a therapeutic target to treat these diseases. Barbara Nikolajczyk, PhD, associate professor of microbiology at BUSM, is the study's senior ...
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Researchers have determined the complete three-dimensional structure of a protein called HNF-4 (and) #945;. HNF-4 (and) #945; controls gene expression in the liver and pancreas, switching genes on or off as needed. The researchers are from the Sanford-Burnham Medical Research Institute (Sanford-Burnham). People with mature onset diabetes of the young (MODY1), a rare form of the disease, have inherited mutations in the HNF-4 (and) #945; protein. This first-ever look at HNF-4 (and) #945;'s full structure, ...
