Molecule's Structure Reveals New Therapeutic Opportunities for Rare Diabetes: Researchers

Researchers have determined the complete three-dimensional structure of a protein called HNF-4 (and) #945;. HNF-4 (and) #945; controls gene expression in the liver and pancreas, switching genes on or off as needed. The researchers are from the Sanford-Burnham Medical Research Institute (Sanford-Burnham). People with mature onset diabetes of the young (MODY1), a rare form of the disease, have inherited mutations in the HNF-4 (and) #945; protein. This first-ever look at HNF-4 (and) #945;'s full structure, ...

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