Attaching chains of the small molecule ADP-ribose to proteins is important for a cell's survival. It also serves in repairing DNA damage, making this process a promising target for the development of new cancer drugs. Researchers have now identified a much sought after enzyme that removes such ADP-ribose modifications from proteins by studying a genetic mutation that causes neurodegenerative disease in humans. These findings, published today in iiThe EMBO ...
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